This is an auto-generated stub page built from atlas entry frontmatter. A richer
hand-crafted page is planned. See the
atlas source
for the full entry including detailed body sections.
mpl
MPL
MPL (CD110) is the thrombopoietin receptor; pre-formed homodimer recruits JAK2 upon TPO binding → STAT5/STAT3 → megakaryopoiesis; MPL W515L/K mutations drive ET (~5-8%) and PMF (~8%); LOF mutations cause congenital amegakaryocytic thrombocytopenia; TPO-mimetics target MPL.
Entry Metadata
| Field | Value |
|---|---|
| ID | mpl |
| Name | MPL |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Pikman Y, Lee BH, Mercher T, et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 2006;3(7):e270. · PubMed 16834459
- Ballmaier M, Germeshausen M, Schulze H, et al. c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia. Blood. 2001;97(1):139-146. · PubMed 11133753