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ferroportin
Ferroportin
Ferroportin (SLC40A1/FPN1) is the sole cellular iron exporter; expressed on enterocytes, macrophages, and hepatocytes; hepcidin binds FPN → internalization → lysosomal degradation → iron sequestration; SLC40A1 mutations cause type 4 haemochromatosis (ferroportin disease).
Entry Metadata
| Field | Value |
|---|---|
| ID | ferroportin |
| Name | Ferroportin |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Donovan A, Brownlie A, Zhou Y, et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000;403(6771):776-781. · PubMed 10693807
- Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306(5704):2090-2093. · PubMed 15514116
- Billesbølle CB, Azumaya CM, Kretschmer RC, et al. Structure of hepcidin-bound ferroportin reveals iron homeostasis regulation. Nature. 2020;586(7831):807-811. · PubMed 32908311