Atlas One · Host Biology · Scale 07 — System

Myeloproliferative Neoplasms

Myeloproliferative neoplasms (PV, ET, MF) are driven by JAK2 V617F in >95% of PV and ~50-60% of ET/MF; CALR and MPL mutations account for remaining cases. Ruxolitinib (JAK1/2 inhibitor) is standard for myelofibrosis and PV; alloSCT is curative for high-risk MF.

Also known as: myeloproliferative neoplasms, MPN, polycythemia vera, PV, essential thrombocythemia, ET, myelofibrosis, MF, primary myelofibrosis, JAK2 V617F MPN, Philadelphia-negative MPN

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
myeloproliferative-neoplasms

Myeloproliferative Neoplasms

Myeloproliferative neoplasms (PV, ET, MF) are driven by JAK2 V617F in >95% of PV and ~50-60% of ET/MF; CALR and MPL mutations account for remaining cases. Ruxolitinib (JAK1/2 inhibitor) is standard for myelofibrosis and PV; alloSCT is curative for high-risk MF.

Entry Metadata

FieldValue
IDmyeloproliferative-neoplasms
NameMyeloproliferative Neoplasms
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toJak1 2 connects-toStat3 connects-toErythropoietin connects-toTgf Beta connects-toPolycythemia Vera connects-toJak2 connects-toBone Marrow connects-toCmml connects-toMyelofibrosis connects-toSpleen connects-toEssential Thrombocythemia connects-toPlatelet connects-toVenous Thromboembolism connects-toCml connects-toAml connects-toGout connects-toCalr connects-toMpl connects-toErythrocyte connects-toNeutrophil connects-toStroke connects-toLiver connects-toThrombopoietin connects-toFibrosis connects-toIron connects-toIl 6 connects-toNatural Killer Cell connects-toAutophagy connects-toPotassium connects-toBrain connects-toNf Kb connects-toSkin connects-toMast Cell connects-toOxygen connects-toElectron connects-toLung connects-toKidney connects-toHeart connects-toLarge Intestine connects-toPhosphorus connects-toEndothelial Cell connects-toHistamine connects-toEye connects-toReproductive System connects-toOsteoblast connects-toVegf connects-toTet2 connects-toAtherosclerosis connects-toMacrophage connects-toDnmt3A connects-toMds connects-toFibroblast connects-toHcc connects-toPulmonary Arterial Hypertension connects-toSepsis connects-toAnemia Of Chronic Disease connects-toAspergillus Fumigatus connects-toMajor Depressive Disorder connects-toVaricella Zoster Virus connects-toIron Deficiency Anemia connects-toGeneralized Anxiety Disorder connects-toDigestive System connects-toIntegumentary System connects-toCardiovascular System connects-toLymphatic System connects-toNervous System connects-toMusculoskeletal System connects-toRespiratory System connects-toRenal System connects-toAspirin connects-toTargeted Therapy connects-toMycobacterium Tuberculosis connects-toCancer Chemotherapy connects-toHepatic Lobule connects-toArterial Wall connects-toCkd connects-toMyocardium connects-toAntiphospholipid Syndrome connects-toCortical Bone connects-toVon Willebrand Factor connects-toGlomerulus connects-toCovid 19 Disease connects-toType I Interferon connects-toEzh2 connects-toIl 1B connects-toTnf Alpha connects-toNlrp3 Inflammasome connects-toHif 1Alpha connects-toPf4 connects-toS100A8 A9 connects-toRunx1 connects-toPdgf connects-toProstaglandins connects-toXanthine Oxidase connects-toSf3B1 connects-toThrombin connects-toFoxo connects-toErk1 2 connects-toPik3Ca connects-toP53 connects-toAkt connects-toMyd88 connects-toCdkn2A connects-toMtor connects-toStat1 connects-toGalectin 3 connects-toCgas Sting connects-toSmad4 connects-toCdk4 6 connects-toGsk 3B connects-toMdm2 connects-toPerforin connects-toSrc Kinase connects-toAmpk connects-toArid1A connects-toCcr5 connects-toCxcl12 connects-toNotch connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toAdenosine connects-toOsteopontin connects-toHemoglobin connects-toTroponin Complex connects-toNitric Oxide connects-toAdamts13 connects-toProtein C connects-toIl 10 connects-toEndothelin 1 connects-toSerotonin connects-toAngiopoietin connects-toHepcidin connects-toIl 4 connects-toLeptin connects-toIl 13 connects-toAdiponectin connects-toResistin connects-toT Cytotoxic Cell connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toDendritic Cell connects-toT Helper Cell connects-toComplement C5 connects-toC5Ar1 connects-toFactor H connects-toTransferrin connects-toTslp connects-toBradykinin connects-toPeriostin connects-toC1 Esterase Inhibitor connects-toMelatonin connects-toProlactin connects-toTestosterone connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toZinc connects-toCalcium connects-toChloride connects-toSulfur connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toIl 2 connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine connects-toRenin

Sources