Atlas One · Host Biology · Scale 07 — System

Chronic Myelomonocytic Leukemia

Chronic myelomonocytic leukemia (CMML) is an MDS/MPN overlap with persistent monocytosis; TET2 (~60%) and SRSF2 (~45%) are the dominant mutations; PDGFRB rearrangements → imatinib-responsive CMML-like disease. Azacitidine is standard; allo-SCT is the only cure; OS ~2 years.

Also known as: CMML, chronic myelomonocytic leukemia, CMML-0, CMML-1, CMML-2, myelodysplastic/myeloproliferative neoplasm, MDS/MPN overlap, proliferative CMML, myelodysplastic CMML

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
cmml

Chronic Myelomonocytic Leukemia

Chronic myelomonocytic leukemia (CMML) is an MDS/MPN overlap with persistent monocytosis; TET2 (~60%) and SRSF2 (~45%) are the dominant mutations; PDGFRB rearrangements → imatinib-responsive CMML-like disease. Azacitidine is standard; allo-SCT is the only cure; OS ~2 years.

Entry Metadata

FieldValue
IDcmml
NameChronic Myelomonocytic Leukemia
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toSrsf2 connects-toDnmt3A connects-toKras connects-toNf Kb connects-toTet2 connects-toJak2 connects-toMacrophage connects-toMyeloproliferative Neoplasms connects-toMds connects-toBone Marrow connects-toAml connects-toCml connects-toDendritic Cell connects-toNeutrophil connects-toSpleen connects-toMyelofibrosis connects-toErythrocyte connects-toRunx1 connects-toEssential Thrombocythemia connects-toPlatelet connects-toImmune System connects-toSkin connects-toLiver connects-toT Cytotoxic Cell connects-toGout connects-toKidney connects-toNatural Killer Cell connects-toIl 6 connects-toOxygen connects-toLung connects-toMtor connects-toIron connects-toHeart connects-toRegulatory T Cell connects-toPhoton connects-toPotassium connects-toFibrosis connects-toElectron connects-toCalcium connects-toLarge Intestine connects-toAntibody connects-toPancreas connects-toEye connects-toStreptococcus Pneumoniae connects-toP53 connects-toMast Cell connects-toGvhd connects-toAnca Vasculitis connects-toT Helper Cell connects-toNlrp3 Inflammasome connects-toPolycythemia Vera connects-toAplastic Anemia connects-toStat3 connects-toSepsis connects-toVenous Thromboembolism connects-toAspergillus Fumigatus connects-toAnemia Of Chronic Disease connects-toHeart Failure connects-toPneumocystis Jirovecii connects-toCkd connects-toMajor Depressive Disorder connects-toIntegumentary System connects-toDigestive System connects-toGeneralized Anxiety Disorder connects-toLymphatic System connects-toRenal System connects-toRespiratory System connects-toMusculoskeletal System connects-toCardiovascular System connects-toNervous System connects-toCancer Chemotherapy connects-toAtherosclerosis connects-toEndothelial Cell connects-toTargeted Therapy connects-toHepatic Lobule connects-toRheumatoid Arthritis connects-toArterial Wall connects-toTnf Alpha connects-toStroke connects-toGiant Cell Arteritis connects-toGlomerulus connects-toAlveolus connects-toEzh2 connects-toIdh2 connects-toFlt3 connects-toIl 1B connects-toHif 1Alpha connects-toVegf connects-toErk1 2 connects-toPtpn11 connects-toS100A8 A9 connects-toCcl2 connects-toJak1 2 connects-toKit connects-toBcl 2 connects-toCxcl12 connects-toPerforin connects-toPik3Ca connects-toAkt connects-toCdkn2A connects-toMyd88 connects-toTgf Beta connects-toWnt Beta Catenin connects-toGalectin 3 connects-toPten connects-toSmad4 connects-toStat1 connects-toCgas Sting connects-toCdk4 6 connects-toFoxo connects-toGsk 3B connects-toMdm2 connects-toSrc Kinase connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toArid1A connects-toIdh1 connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toAdenosine connects-toOsteopontin connects-toXanthine Oxidase connects-toHemoglobin connects-toMhc Class Ii connects-toIl 10 connects-toTroponin Complex connects-toIl 2 connects-toErythropoietin connects-toThrombopoietin connects-toProstaglandins connects-toIl 4 connects-toNeutrophil connects-toIron connects-toLeptin connects-toAdiponectin connects-toIl 13 connects-toResistin connects-toMyeloproliferative Neoplasms connects-toNeutrophil connects-toIfn Gamma connects-toIl 12 connects-toType I Interferon connects-toIl 5 connects-toIl 23 connects-toIge connects-toC5Ar1 connects-toComplement C5 connects-toTransferrin connects-toFactor H connects-toC1 Esterase Inhibitor connects-toPeriostin connects-toTslp connects-toBradykinin connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toProlactin connects-toSerotonin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toZinc connects-toPhosphorus connects-toChloride connects-toSulfur connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr

Sources