Atlas One · Host Biology · Scale 03 — Molecular

KIT

KIT (CD117) is a type III RTK activated by SCF; KIT gain-of-function mutations in ~85% of GIST (exon 11 juxtamembrane most common) and KIT D816V in systemic mastocytosis; imatinib is first-line for GIST; avapritinib is approved for PDGFRA D842V and systemic mastocytosis.

Also known as: KIT, c-KIT, CD117, SCFR, stem cell factor receptor, KIT mutation, KIT D816V, imatinib GIST, tyrosine kinase KIT, gastrointestinal stromal tumor KIT

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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kit

KIT

KIT (CD117) is a type III RTK activated by SCF; KIT gain-of-function mutations in ~85% of GIST (exon 11 juxtamembrane most common) and KIT D816V in systemic mastocytosis; imatinib is first-line for GIST; avapritinib is approved for PDGFRA D842V and systemic mastocytosis.

Entry Metadata

FieldValue
IDkit
NameKIT
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toPdgf connects-toMtor connects-toErk1 2 connects-toSrc Kinase

Sources