Atlas One · Host Biology · Scale 03 — Molecular

SRSF2

SRSF2 encodes a spliceosome serine-arginine protein; P95H hotspot alters CCNG exonic splicing enhancer recognition → aberrant mRNA splicing; SRSF2 P95H mutations occur in ~45% of CMML (with TET2 co-mutation), ~15% of MDS, and ~11% of PTCL; no direct targeted therapy.

Also known as: SRSF2, SC35, serine-arginine splicing factor 2, SRSF2 P95H, splicing factor mutation MDS, splicing factor CMML, spliceosome mutation, SRSF2 myeloid

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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srsf2

SRSF2

SRSF2 encodes a spliceosome serine-arginine protein; P95H hotspot alters CCNG exonic splicing enhancer recognition → aberrant mRNA splicing; SRSF2 P95H mutations occur in ~45% of CMML (with TET2 co-mutation), ~15% of MDS, and ~11% of PTCL; no direct targeted therapy.

Entry Metadata

FieldValue
IDsrsf2
NameSRSF2
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toDnmt3A connects-toEzh2 connects-toNf Kb connects-toKras

Sources