Atlas One · Host Biology · Scale 07 — System

Chronic Myeloid Leukemia

Clonal myeloid leukemia driven by t(9;22)/BCR-ABL (Philadelphia chromosome); imatinib (IRIS trial) transformed CML from fatal to chronic; 5-year OS >85%. TKI-refractory T315I → ponatinib or asciminib; treatment-free remission achievable in ~50% of deep molecular responders.

Also known as: CML, chronic myelogenous leukemia, Philadelphia chromosome leukemia, BCR-ABL leukemia

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
cml

Chronic Myeloid Leukemia

Clonal myeloid leukemia driven by t(9;22)/BCR-ABL (Philadelphia chromosome); imatinib (IRIS trial) transformed CML from fatal to chronic; 5-year OS >85%. TKI-refractory T315I → ponatinib or asciminib; treatment-free remission achievable in ~50% of deep molecular responders.

Entry Metadata

FieldValue
IDcml
NameChronic Myeloid Leukemia
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toAbl1 connects-toStat3 connects-toMtor connects-toSrc Kinase connects-toAkt connects-toMyc connects-toRb1 connects-toNeutrophil connects-toBone Marrow connects-toCll connects-toMyeloproliferative Neoplasms connects-toAml connects-toSpleen connects-toAll connects-toPlatelet connects-toMds connects-toJak2 connects-toPolycythemia Vera connects-toLiver connects-toErythrocyte connects-toGout connects-toEssential Thrombocythemia connects-toImmune System connects-toT Cytotoxic Cell connects-toPhoton connects-toAutophagy connects-toNatural Killer Cell connects-toPotassium connects-toWnt Beta Catenin connects-toKidney connects-toDendritic Cell connects-toOxygen connects-toBrain connects-toMacrophage connects-toPhosphorus connects-toEye connects-toFibrosis connects-toElectron connects-toLung connects-toSkin connects-toHeart connects-toReproductive System connects-toLarge Intestine connects-toEndothelial Cell connects-toTgf Beta connects-toCalcium connects-toGvhd connects-toRegulatory T Cell connects-toIl 6 connects-toMyelofibrosis connects-toBcl 2 connects-toStroke connects-toNf Kb connects-toVenous Thromboembolism connects-toSepsis connects-toPulmonary Arterial Hypertension connects-toHeart Failure connects-toMajor Depressive Disorder connects-toAtherosclerosis connects-toAnemia Of Chronic Disease connects-toAspergillus Fumigatus connects-toDigestive System connects-toIntegumentary System connects-toGeneralized Anxiety Disorder connects-toLymphatic System connects-toRespiratory System connects-toEndocrine System connects-toCardiovascular System connects-toMusculoskeletal System connects-toRenal System connects-toTargeted Therapy connects-toGist connects-toCancer Chemotherapy connects-toArterial Wall connects-toCortical Bone connects-toMyocardium connects-toCmml connects-toHepatic Lobule connects-toType 2 Diabetes connects-toCardiac Conduction System connects-toAlveolus connects-toCovid 19 Disease connects-toKit connects-toFoxo connects-toHif 1Alpha connects-toEzh2 connects-toCyclin D1 connects-toVegf connects-toErk1 2 connects-toCxcl12 connects-toRunx1 connects-toSmo connects-toCaspase 3 connects-toTert connects-toPerforin connects-toDnmt3A connects-toMdm2 connects-toKras connects-toPik3Ca connects-toE2F1 connects-toP53 connects-toCdkn2A connects-toNfe2L2 connects-toGalectin 3 connects-toPten connects-toSmad4 connects-toStat1 connects-toCgas Sting connects-toCdk4 6 connects-toGsk 3B connects-toS100A8 A9 connects-toJak1 2 connects-toAmpk connects-toCcl2 connects-toNotch connects-toCcr5 connects-toArid1A connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toAdenosine connects-toOsteopontin connects-toMhc Class Ii connects-toXanthine Oxidase connects-toIl 2 connects-toHemoglobin connects-toTroponin Complex connects-toInsulin connects-toNitric Oxide connects-toCholesterol connects-toIron connects-toIl 4 connects-toPf4 connects-toLeptin connects-toAdiponectin connects-toResistin connects-toIron connects-toPlatelet connects-toAml connects-toAll connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 13 connects-toIl 23 connects-toC5Ar1 connects-toMast Cell connects-toT Helper Cell connects-toComplement C5 connects-toFactor H connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toC1 Esterase Inhibitor connects-toTestosterone connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toZinc connects-toChloride connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine

Sources