Atlas One · Host Biology · Scale 03 — Molecular

ABL1

Non-receptor tyrosine kinase; fused with BCR in CML (t(9;22)) → constitutive BCR-ABL → RAS-MAPK, STAT5, and PI3K → leukemic proliferation. Imatinib, dasatinib, nilotinib are ABL inhibitors; asciminib (STAMP) and ponatinib overcome T315I gatekeeper resistance.

Also known as: ABL, ABL1, BCR-ABL, BCR-ABL1, c-ABL, Philadelphia chromosome kinase, p210 BCR-ABL, CML kinase, Abelson kinase

Scale 03 — MolecularScale
draftStatus
2026-06-06Last Reviewed
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abl1

ABL1

Non-receptor tyrosine kinase; fused with BCR in CML (t(9;22)) → constitutive BCR-ABL → RAS-MAPK, STAT5, and PI3K → leukemic proliferation. Imatinib, dasatinib, nilotinib are ABL inhibitors; asciminib (STAMP) and ponatinib overcome T315I gatekeeper resistance.

Entry Metadata

FieldValue
IDabl1
NameABL1
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toSrc Kinase connects-toStat3 connects-toMtor connects-toKras connects-toP53 connects-toNatural Killer Cell connects-toRad51

Sources