Atlas One · Host Biology · Scale 07 — System

GIST

GIST is the most common GI mesenchymal tumor, arising from ICC precursors; KIT exon 11 mutations in ~70% and PDGFRA mutations in ~10% drive constitutive RTK signaling. Imatinib is standard first-line; adjuvant imatinib (3 years) reduces recurrence for high-risk GIST.

Also known as: GIST, gastrointestinal stromal tumor, KIT-mutant GIST, imatinib GIST, PDGFRA D842V GIST, SDH-deficient GIST, CD117 positive tumor

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
gist

GIST

GIST is the most common GI mesenchymal tumor, arising from ICC precursors; KIT exon 11 mutations in ~70% and PDGFRA mutations in ~10% drive constitutive RTK signaling. Imatinib is standard first-line; adjuvant imatinib (3 years) reduces recurrence for high-risk GIST.

Entry Metadata

FieldValue
IDgist
NameGIST
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toPdgf connects-toVegf connects-toMtor connects-toSrc Kinase connects-toKit connects-toNf1 connects-toBraf connects-toDesmoid Tumor connects-toStomach connects-toNeurofibromatosis Type 1 connects-toSmall Intestine connects-toPheochromocytoma Paraganglioma connects-toDigestive System connects-toGastric Cancer connects-toSynovial Sarcoma connects-toColorectal Cancer connects-toSmooth Muscle Cell connects-toLiver connects-toAkt connects-toCarney Complex connects-toRhabdomyosarcoma connects-toErythrocyte connects-toMast Cell connects-toT Cytotoxic Cell connects-toPhoton connects-toSdhb connects-toNatural Killer Cell connects-toMacrophage connects-toOxygen connects-toLarge Intestine connects-toDendritic Cell connects-toIron connects-toEndothelial Cell connects-toAdrenal Gland connects-toIntestinal Epithelium connects-toCalcium connects-toNeuron connects-toElectron connects-toBone Marrow connects-toLung connects-toAntibody connects-toHeart connects-toReproductive System connects-toHif 1Alpha connects-toCardiomyocyte connects-toRegulatory T Cell connects-toFibroblast connects-toMelanoma connects-toCyclin D1 connects-toIron Deficiency Anemia connects-toAutophagy connects-toVenous Thromboembolism connects-toStat3 connects-toNf Kb connects-toSepsis connects-toAnemia Of Chronic Disease connects-toHeart Failure connects-toCkd connects-toWound Healing connects-toNeuropathic Pain connects-toMajor Depressive Disorder connects-toIntegumentary System connects-toEndocrine System connects-toGeneralized Anxiety Disorder connects-toCardiovascular System connects-toLymphatic System connects-toRenal System connects-toMusculoskeletal System connects-toRespiratory System connects-toNervous System connects-toTargeted Therapy connects-toCml connects-toCancer Chemotherapy connects-toCheckpoint Inhibitors connects-toAml connects-toMpnst connects-toHepatic Lobule connects-toRenal Cell Carcinoma connects-toErk1 2 connects-toNeuroendocrine Tumors connects-toCardiac Conduction System connects-toAlveolus connects-toIgf 1 connects-toNtrk connects-toFgfr connects-toEzh2 connects-toMyc connects-toTert connects-toCdkn2A connects-toP53 connects-toCcl2 connects-toCaspase 3 connects-toCxcl12 connects-toEgln1 connects-toDnmt3A connects-toBcl 2 connects-toFoxo connects-toPik3Ca connects-toPten connects-toE2F1 connects-toKras connects-toRb1 connects-toJak1 2 connects-toEpas1 connects-toGalectin 3 connects-toTgf Beta connects-toStat1 connects-toCdk4 6 connects-toCgas Sting connects-toGsk 3B connects-toMdm2 connects-toPerforin connects-toS100A8 A9 connects-toAmpk connects-toNotch connects-toCcr5 connects-toArid1A connects-toIl 6 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toOsteopontin connects-toMhc Class Ii connects-toAxl Receptor connects-toPd 1 connects-toHemoglobin connects-toTroponin Complex connects-toIl 2 connects-toNeurofibromatosis Type 1 connects-toCarney Complex connects-toIl 10 connects-toIl 4 connects-toMacrophage connects-toIron connects-toIl 13 connects-toLeptin connects-toHepcidin connects-toAdiponectin connects-toResistin connects-toNeutrophil connects-toIfn Gamma connects-toIl 12 connects-toType I Interferon connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Helper Cell connects-toB Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSerotonin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toZinc connects-toPotassium connects-toPhosphorus connects-toCarbon connects-toChloride connects-toHydrogen connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toFibronectin connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toEpinephrine connects-toRenin

Sources