Atlas One · Host Biology · Scale 07 — System

GIST

GIST is the most common GI mesenchymal tumor, arising from ICC precursors; KIT exon 11 mutations in ~70% and PDGFRA mutations in ~10% drive constitutive RTK signaling. Imatinib is standard first-line; adjuvant imatinib (3 years) reduces recurrence for high-risk GIST.

Also known as: GIST, gastrointestinal stromal tumor, KIT-mutant GIST, imatinib GIST, PDGFRA D842V GIST, SDH-deficient GIST, CD117 positive tumor

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
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gist

GIST

GIST is the most common GI mesenchymal tumor, arising from ICC precursors; KIT exon 11 mutations in ~70% and PDGFRA mutations in ~10% drive constitutive RTK signaling. Imatinib is standard first-line; adjuvant imatinib (3 years) reduces recurrence for high-risk GIST.

Entry Metadata

FieldValue
IDgist
NameGIST
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toPdgf connects-toVegf connects-toMtor connects-toSrc Kinase connects-toKit connects-toNf1 connects-toBraf connects-toDesmoid Tumor connects-toStomach connects-toNeurofibromatosis Type 1 connects-toSmall Intestine connects-toPheochromocytoma Paraganglioma connects-toDigestive System

Sources