Atlas One · Host Biology · Scale 07 — System

Peutz-Jeghers Syndrome

Peutz-Jeghers syndrome (PJS) is caused by germline STK11/LKB1 mutations; hamartomatous GI polyps + mucocutaneous melanotic spots; cumulative cancer risk by age 70: breast 45%, CRC 39%, pancreatic 36%; intussusception risk; surveillance from age 8.

Also known as: Peutz-Jeghers syndrome, PJS, STK11 hamartoma, LKB1 polyp syndrome, Peutz-Jeghers, hereditary hamartomatous polyposis, PJ polyp, STK11 cancer syndrome, hamartomatous polyposis, Peutz-Jeghers cancer risk

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
peutz-jeghers-syndrome

Peutz-Jeghers Syndrome

Peutz-Jeghers syndrome (PJS) is caused by germline STK11/LKB1 mutations; hamartomatous GI polyps + mucocutaneous melanotic spots; cumulative cancer risk by age 70: breast 45%, CRC 39%, pancreatic 36%; intussusception risk; surveillance from age 8.

Entry Metadata

FieldValue
IDpeutz-jeghers-syndrome
NamePeutz-Jeghers Syndrome
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toStk11 connects-toAmpk connects-toColorectal Cancer connects-toPancreatic Cancer connects-toMtor connects-toBreast Cancer connects-toNsclc connects-toSmall Intestine connects-toSkin connects-toSmooth Muscle Cell connects-toJuvenile Polyposis Syndrome connects-toOvarian Cancer connects-toCervical Cancer connects-toCowden Syndrome connects-toFap connects-toGastric Cancer connects-toLarge Intestine connects-toIntestinal Epithelium connects-toWnt Beta Catenin connects-toDigestive System connects-toIntegumentary System connects-toReproductive System connects-toStomach connects-toIron Deficiency Anemia connects-toMutyh Associated Polyposis connects-toEstrogen connects-toAkt connects-toFibroblast connects-toIron connects-toMacrophage connects-toVegf connects-toCopper connects-toPancreas connects-toEndothelial Cell connects-toPhoton connects-toLung connects-toLiver connects-toErythrocyte connects-toElectron connects-toEndometrial Cancer connects-toAntibody connects-toThyroid connects-toPlatelet connects-toInsulin connects-toT Cytotoxic Cell connects-toAdipocyte connects-toP53 connects-toSclc connects-toCholangiocarcinoma connects-toLynch Syndrome connects-toSepsis connects-toVenous Thromboembolism connects-toStat3 connects-toNf Kb connects-toAnemia Of Chronic Disease connects-toEsophageal Cancer connects-toOsteoporosis connects-toMajor Depressive Disorder connects-toWound Healing connects-toEndocrine System connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toGut Microbiome connects-toImmune System connects-toLymphatic System connects-toCardiovascular System connects-toMusculoskeletal System connects-toTargeted Therapy connects-toHereditary Diffuse Gastric Cancer connects-toDietary Fiber connects-toCancer Chemotherapy connects-toCarney Complex connects-toCheckpoint Inhibitors connects-toMetformin connects-toTuberous Sclerosis Complex connects-toAutophagy connects-toDicer1 Syndrome connects-toAlveolus connects-toLi Fraumeni Syndrome connects-toNeuroendocrine Tumors connects-toMen1 Syndrome connects-toHepatic Lobule connects-toProstaglandins connects-toTsc1 Tsc2 connects-toMyc connects-toCyclin D1 connects-toErk1 2 connects-toHif 1Alpha connects-toCdkn1A connects-toFoxo1 connects-toPten connects-toKras connects-toSmad4 connects-toCaspase 3 connects-toCdkn1B connects-toAdiponectin connects-toTgf Beta connects-toPik3Ca connects-toE2F1 connects-toCdh1 connects-toIl 6 connects-toMyd88 connects-toRb1 connects-toGalectin 3 connects-toJak1 2 connects-toCgas Sting connects-toStat1 connects-toFoxo connects-toCdk4 6 connects-toGsk 3B connects-toMdm2 connects-toS100A8 A9 connects-toSrc Kinase connects-toDnmt3A connects-toPerforin connects-toCcr5 connects-toArid1A connects-toEzh2 connects-toCxcl12 connects-toIl 1B connects-toIl 33 connects-toLeptin connects-toTestosterone connects-toActivin A connects-toHemoglobin connects-toEndothelin 1 connects-toProgesterone connects-toMu Opioid Receptor connects-toXanthine Oxidase connects-toIl 10 connects-toIl 4 connects-toCholesterol connects-toNitric Oxide connects-toIl 13 connects-toResistin connects-toHepcidin connects-toPdgf connects-toZinc connects-toCalcium connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toT Helper Cell connects-toDendritic Cell connects-toB Cell connects-toComplement C3 connects-toC5Ar1 connects-toTslp connects-toPeriostin connects-toHistamine connects-toBradykinin connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toMelatonin connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toMagnesium connects-toPotassium connects-toPhosphorus connects-toChloride connects-toCarbon connects-toHydrogen connects-toNitrogen connects-toOxygen connects-toSulfur connects-toPd 1 connects-toGlp 1 connects-toAngiotensin Ii connects-toRankl connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr