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peutz-jeghers-syndrome
Peutz-Jeghers Syndrome
Peutz-Jeghers syndrome (PJS) is caused by germline STK11/LKB1 mutations; hamartomatous GI polyps + mucocutaneous melanotic spots; cumulative cancer risk by age 70: breast 45%, CRC 39%, pancreatic 36%; intussusception risk; surveillance from age 8.
Entry Metadata
| Field | Value |
|---|---|
| ID | peutz-jeghers-syndrome |
| Name | Peutz-Jeghers Syndrome |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toStk11
connects-toAmpk
connects-toColorectal Cancer
connects-toPancreatic Cancer
connects-toMtor
connects-toBreast Cancer
connects-toNsclc
connects-toSmall Intestine
connects-toSkin
connects-toSmooth Muscle Cell
connects-toJuvenile Polyposis Syndrome
connects-toOvarian Cancer
connects-toCervical Cancer
connects-toCowden Syndrome
connects-toFap
connects-toGastric Cancer
connects-toLarge Intestine
connects-toIntestinal Epithelium
connects-toWnt Beta Catenin
connects-toDigestive System
connects-toIntegumentary System
connects-toReproductive System
connects-toStomach
connects-toIron Deficiency Anemia
connects-toMutyh Associated Polyposis
connects-toEstrogen
connects-toAkt
connects-toFibroblast
connects-toIron
connects-toMacrophage
connects-toVegf
connects-toCopper
connects-toPancreas
connects-toEndothelial Cell
connects-toPhoton
connects-toLung
connects-toLiver
connects-toErythrocyte
connects-toElectron
connects-toEndometrial Cancer
connects-toAntibody
connects-toThyroid
connects-toPlatelet
connects-toInsulin
connects-toT Cytotoxic Cell
connects-toAdipocyte
connects-toP53
connects-toSclc
connects-toCholangiocarcinoma
connects-toLynch Syndrome
connects-toSepsis
connects-toVenous Thromboembolism
connects-toStat3
connects-toNf Kb
connects-toAnemia Of Chronic Disease
connects-toEsophageal Cancer
connects-toOsteoporosis
connects-toMajor Depressive Disorder
connects-toWound Healing
connects-toEndocrine System
connects-toGeneralized Anxiety Disorder
connects-toRespiratory System
connects-toGut Microbiome
connects-toImmune System
connects-toLymphatic System
connects-toCardiovascular System
connects-toMusculoskeletal System
connects-toTargeted Therapy
connects-toHereditary Diffuse Gastric Cancer
connects-toDietary Fiber
connects-toCancer Chemotherapy
connects-toCarney Complex
connects-toCheckpoint Inhibitors
connects-toMetformin
connects-toTuberous Sclerosis Complex
connects-toAutophagy
connects-toDicer1 Syndrome
connects-toAlveolus
connects-toLi Fraumeni Syndrome
connects-toNeuroendocrine Tumors
connects-toMen1 Syndrome
connects-toHepatic Lobule
connects-toProstaglandins
connects-toTsc1 Tsc2
connects-toMyc
connects-toCyclin D1
connects-toErk1 2
connects-toHif 1Alpha
connects-toCdkn1A
connects-toFoxo1
connects-toPten
connects-toKras
connects-toSmad4
connects-toCaspase 3
connects-toCdkn1B
connects-toAdiponectin
connects-toTgf Beta
connects-toPik3Ca
connects-toE2F1
connects-toCdh1
connects-toIl 6
connects-toMyd88
connects-toRb1
connects-toGalectin 3
connects-toJak1 2
connects-toCgas Sting
connects-toStat1
connects-toFoxo
connects-toCdk4 6
connects-toGsk 3B
connects-toMdm2
connects-toS100A8 A9
connects-toSrc Kinase
connects-toDnmt3A
connects-toPerforin
connects-toCcr5
connects-toArid1A
connects-toEzh2
connects-toCxcl12
connects-toIl 1B
connects-toIl 33
connects-toLeptin
connects-toTestosterone
connects-toActivin A
connects-toHemoglobin
connects-toEndothelin 1
connects-toProgesterone
connects-toMu Opioid Receptor
connects-toXanthine Oxidase
connects-toIl 10
connects-toIl 4
connects-toCholesterol
connects-toNitric Oxide
connects-toIl 13
connects-toResistin
connects-toHepcidin
connects-toPdgf
connects-toZinc
connects-toCalcium
connects-toType I Interferon
connects-toIfn Gamma
connects-toIl 12
connects-toIl 5
connects-toIl 23
connects-toIge
connects-toMast Cell
connects-toT Helper Cell
connects-toDendritic Cell
connects-toB Cell
connects-toComplement C3
connects-toC5Ar1
connects-toTslp
connects-toPeriostin
connects-toHistamine
connects-toBradykinin
connects-toC1 Esterase Inhibitor
connects-toErythropoietin
connects-toMelatonin
connects-toSerotonin
connects-toProlactin
connects-toOxytocin
connects-toVasopressin
connects-toSelenium
connects-toIodine
connects-toSodium
connects-toMagnesium
connects-toPotassium
connects-toPhosphorus
connects-toChloride
connects-toCarbon
connects-toHydrogen
connects-toNitrogen
connects-toOxygen
connects-toSulfur
connects-toPd 1
connects-toGlp 1
connects-toAngiotensin Ii
connects-toRankl
connects-toIl 2
connects-toFibronectin
connects-toNotch
connects-toIgf 1
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf
connects-toOsteopontin
connects-toFgfr
Sources
- Hearle N, Schumacher V, Menko FH, et al. Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin Cancer Res. 2006;12(10):3209-3215. · PubMed 16707622
- Skoulidis F, Goldberg ME, Greenawalt DM, et al. STK11/LKB1 mutations and PD-1 inhibitor resistance in KRAS-mutant lung adenocarcinoma. Cancer Cell. 2018;34(3):412-424. · PubMed 30174241