Atlas One · Host Biology · Scale 07 — System

Peutz-Jeghers Syndrome

Peutz-Jeghers syndrome (PJS) is caused by germline STK11/LKB1 mutations; hamartomatous GI polyps + mucocutaneous melanotic spots; cumulative cancer risk by age 70: breast 45%, CRC 39%, pancreatic 36%; intussusception risk; surveillance from age 8.

Also known as: Peutz-Jeghers syndrome, PJS, STK11 hamartoma, LKB1 polyp syndrome, Peutz-Jeghers, hereditary hamartomatous polyposis, PJ polyp, STK11 cancer syndrome, hamartomatous polyposis, Peutz-Jeghers cancer risk

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
peutz-jeghers-syndrome

Peutz-Jeghers Syndrome

Peutz-Jeghers syndrome (PJS) is caused by germline STK11/LKB1 mutations; hamartomatous GI polyps + mucocutaneous melanotic spots; cumulative cancer risk by age 70: breast 45%, CRC 39%, pancreatic 36%; intussusception risk; surveillance from age 8.

Entry Metadata

FieldValue
IDpeutz-jeghers-syndrome
NamePeutz-Jeghers Syndrome
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toStk11 connects-toAmpk connects-toColorectal Cancer connects-toPancreatic Cancer connects-toMtor connects-toBreast Cancer connects-toNsclc connects-toSmall Intestine connects-toSkin connects-toSmooth Muscle Cell

Sources