Atlas One · Host Biology · Scale 07 — System

Esophageal Cancer

Esophageal cancer includes ESCC (squamous, smoking/alcohol) and EAC (adenocarcinoma, Barrett's/HER2+ ~15%); nivolumab+chemotherapy (CheckMate 648) is first-line for ESCC; trastuzumab+chemotherapy (ToGA) and T-DXd for HER2+ EAC; 5-year OS ~20%.

Also known as: esophageal cancer, ESCC, esophageal squamous cell carcinoma, EAC, esophageal adenocarcinoma, Barrett's esophagus cancer, GEJ cancer, gastroesophageal junction cancer, CheckMate 648, ATTRACTION-3

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
esophageal-cancer

Esophageal Cancer

Esophageal cancer includes ESCC (squamous, smoking/alcohol) and EAC (adenocarcinoma, Barrett's/HER2+ ~15%); nivolumab+chemotherapy (CheckMate 648) is first-line for ESCC; trastuzumab+chemotherapy (ToGA) and T-DXd for HER2+ EAC; 5-year OS ~20%.

Entry Metadata

FieldValue
IDesophageal-cancer
NameEsophageal Cancer
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toNfe2L2 connects-toPd 1 connects-toHer2 connects-toVegf connects-toEgfr connects-toFgfr connects-toGastric Cancer connects-toHnscc connects-toStomach connects-toT Cytotoxic Cell connects-toObesity connects-toAlcohol Use Disorder connects-toCarbon connects-toPancreatic Cancer connects-toColorectal Cancer connects-toPhoton connects-toHelicobacter Pylori connects-toP53 connects-toLung connects-toDigestive System connects-toHpv 16 connects-toLymphatic System connects-toIron Deficiency Anemia connects-toLiver connects-toSmooth Muscle Cell connects-toCdkn2A connects-toFibroblast connects-toRegulatory T Cell connects-toNitrogen connects-toNf Kb connects-toMacrophage connects-toIron connects-toFibrosis connects-toEndothelial Cell connects-toZinc connects-toIntestinal Epithelium connects-toNatural Killer Cell connects-toElectron connects-toBone Marrow connects-toLarge Intestine connects-toNeuron connects-toAntibody connects-toErythrocyte connects-toHeart connects-toNotch connects-toPlatelet connects-toCyclin D1 connects-toNeutrophil connects-toSystemic Sclerosis connects-toPik3Ca connects-toDendritic Cell connects-toSepsis connects-toStat3 connects-toVenous Thromboembolism connects-toAnemia Of Chronic Disease connects-toCandida Albicans connects-toCkd connects-toMajor Depressive Disorder connects-toNeuropathic Pain connects-toHeart Failure connects-toAspergillus Fumigatus connects-toWound Healing connects-toRespiratory System connects-toGeneralized Anxiety Disorder connects-toCardiovascular System connects-toNervous System connects-toEndocrine System connects-toImmune System connects-toIntegumentary System connects-toMusculoskeletal System connects-toCheckpoint Inhibitors connects-toCancer Chemotherapy connects-toTargeted Therapy connects-toNsclc connects-toPeripheral Nerve connects-toCortical Bone connects-toAlveolus connects-toGerminal Center connects-toBladder Cancer connects-toHepatic Lobule connects-toCopd connects-toMyocardium connects-toMyc connects-toKras connects-toYap1 connects-toAkt connects-toHif 1Alpha connects-toEzh2 connects-toTert connects-toTgf Beta connects-toCcl2 connects-toIl 6 connects-toCxcl12 connects-toCgas Sting connects-toCholesterol connects-toCaspase 3 connects-toLeptin connects-toErk1 2 connects-toMtor connects-toCdh1 connects-toMyd88 connects-toJak1 2 connects-toRb1 connects-toSmad4 connects-toGalectin 3 connects-toPten connects-toStat1 connects-toCdk4 6 connects-toFoxo connects-toPerforin connects-toS100A8 A9 connects-toMdm2 connects-toGsk 3B connects-toSrc Kinase connects-toDnmt3A connects-toAmpk connects-toAutophagy connects-toCcr5 connects-toArid1A connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toComplement C3 connects-toCalcineurin connects-toProton connects-toMhc Class Ii connects-toAxl Receptor connects-toHemoglobin connects-toIl 2 connects-toXanthine Oxidase connects-toProstaglandins connects-toIl 10 connects-toLung connects-toIl 4 connects-toFibroblast connects-toIron connects-toAdiponectin connects-toIl 13 connects-toResistin connects-toSelenium connects-toHepcidin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toT Helper Cell connects-toB Cell connects-toC5Ar1 connects-toComplement C5 connects-toFactor H connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toMelatonin connects-toTestosterone connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSerotonin connects-toIodine connects-toSodium connects-toMagnesium connects-toCopper connects-toPotassium connects-toCalcium connects-toPhosphorus connects-toChloride connects-toHydrogen connects-toOxygen connects-toSulfur connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toFibronectin connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toEpinephrine

Sources