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lung-slice
Lung Slice
Precision-cut lung slices (PCLS): 200–300 μm ex vivo tissue sections retaining intact alveolar and airway architecture. Research models for airway pharmacology, viral infection (SARS-CoV-2, RSV), and pulmonary drug toxicology without live animal experiments.
Entry Metadata
| Field | Value |
|---|---|
| ID | lung-slice |
| Name | Lung Slice |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 05-tissue |
Cross-Atlas Connections
Sources
- Placke ME, Fisher GL. Adult peripheral lung organ culture — a model for respiratory tract toxicology. Toxicol Appl Pharmacol. 1987;90(2):284-298. · PubMed 3616891
- Bergner A, Sanderson MJ. Airway contractility and smooth muscle Ca2+ signaling in lung slices from different mouse strains. J Appl Physiol. 2002;93(4):1300-1309. · PubMed 12235026
- Neuhaus V, Schaudien D, Golovina T, et al. Assessment of long-term cultivated human precision-cut lung slices as a model system for research in respiratory medicine. J Occup Med Toxicol. 2017;12:13. · PubMed 28473872