Atlas One · Host Biology · Scale 03 — Molecular

APC

APC (adenomatous polyposis coli) scaffolds the β-catenin destruction complex (APC-AXIN-GSK-3β-CK1α); LOF → nuclear β-catenin → Wnt pathway activation; mutated in ~80% of sporadic CRC; germline APC = familial adenomatous polyposis; MCR hotspots at codons 1309 and 1450.

Also known as: APC, APC mutation, APC colorectal, APC FAP, adenomatous polyposis coli, APC truncation, APC MCR, APC beta-catenin, APC Wnt, APC colon cancer

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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apc

APC

APC (adenomatous polyposis coli) scaffolds the β-catenin destruction complex (APC-AXIN-GSK-3β-CK1α); LOF → nuclear β-catenin → Wnt pathway activation; mutated in ~80% of sporadic CRC; germline APC = familial adenomatous polyposis; MCR hotspots at codons 1309 and 1450.

Entry Metadata

FieldValue
IDapc
NameAPC
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toCtnnb1 connects-toWnt Beta Catenin connects-toColorectal Cancer connects-toNotch connects-toIntestinal Epithelium connects-toKras connects-toP53

Sources