Atlas One · Host Biology · Scale 03 — Molecular

MUTYH

MUTYH (MutY homolog) is a BER glycosylase that removes adenine mispaired with 8-oxoguanine; LOF → G:C→T:A transversions (SBS18) → somatic APC and KRAS mutations; biallelic germline MUTYH = MUTYH-associated polyposis (MAP); monoallelic variants modestly elevate CRC risk.

Also known as: MUTYH, MYH, MutY homolog, MUTYH glycosylase, MUTYH MAP, MUTYH BER, MUTYH 8-oxoguanine, MUTYH colorectal cancer, MUTYH-associated polyposis gene

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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mutyh

MUTYH

MUTYH (MutY homolog) is a BER glycosylase that removes adenine mispaired with 8-oxoguanine; LOF → G:C→T:A transversions (SBS18) → somatic APC and KRAS mutations; biallelic germline MUTYH = MUTYH-associated polyposis (MAP); monoallelic variants modestly elevate CRC risk.

Entry Metadata

FieldValue
IDmutyh
NameMUTYH
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toApc connects-toColorectal Cancer connects-toFap connects-toMutyh Associated Polyposis connects-toKras connects-toMsh2 connects-toP53

Sources