Atlas One · Host Biology · Scale 07 — System

Wilms Tumor

Wilms tumor (nephroblastoma) is the most common pediatric renal malignancy; peak age 3-4 years; favorable histology ~90% with 4-year OS >95%; anaplastic ~10% with TP53 mutations; WT1/CTNNB1/WTX/DROSHA drivers; actinomycin D+vincristine±doxorubicin backbone.

Also known as: Wilms tumor, nephroblastoma, Wilms' tumor, pediatric kidney cancer, childhood renal tumor, nephroblastoma WAGR, Wilms anaplastic

Scale 07 — SystemScale
draftStatus
2026-06-06Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
wilms-tumor

Wilms Tumor

Wilms tumor (nephroblastoma) is the most common pediatric renal malignancy; peak age 3-4 years; favorable histology ~90% with 4-year OS >95%; anaplastic ~10% with TP53 mutations; WT1/CTNNB1/WTX/DROSHA drivers; actinomycin D+vincristine±doxorubicin backbone.

Entry Metadata

FieldValue
IDwilms-tumor
NameWilms Tumor
Statusdraft
Last reviewed2026-06-06
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toWt1 connects-toWnt Beta Catenin connects-toP53 connects-toMtor connects-toKidney connects-toPodocyte connects-toIgf 1 connects-toRhabdomyosarcoma connects-toNeuroblastoma connects-toLi Fraumeni Syndrome connects-toRenal Cell Carcinoma connects-toEwing Sarcoma connects-toRetinoblastoma connects-toPhoton connects-toAtypical Teratoid Rhabdoid Tumor connects-toMedulloblastoma connects-toCtnnb1 connects-toLung connects-toDicer1 Syndrome connects-toReproductive System connects-toEye connects-toLiver connects-toDicer1 connects-toGlomerulus connects-toFibroblast connects-toVegf connects-toMacrophage connects-toNatural Killer Cell connects-toAkt connects-toOxygen connects-toDendritic Cell connects-toHeart connects-toEndothelial Cell connects-toMycn connects-toElectron connects-toBone Marrow connects-toBrain connects-toHypertension connects-toNeuron connects-toErythrocyte connects-toAntibody connects-toNeutrophil connects-toMagnesium connects-toRenin connects-toCardiomyocyte connects-toPlatelet connects-toRenal System connects-toErythropoietin connects-toT Cytotoxic Cell connects-toVenous Thromboembolism connects-toStat3 connects-toSepsis connects-toCkd connects-toHeart Failure connects-toAnemia Of Chronic Disease connects-toAspergillus Fumigatus connects-toOsteoporosis connects-toMajor Depressive Disorder connects-toWound Healing connects-toNeuropathic Pain connects-toGeneralized Anxiety Disorder connects-toRespiratory System connects-toCardiovascular System connects-toDigestive System connects-toLymphatic System connects-toMusculoskeletal System connects-toEndocrine System connects-toImmune System connects-toNervous System connects-toIntegumentary System connects-toCancer Chemotherapy connects-toCheckpoint Inhibitors connects-toCortical Bone connects-toAlveolus connects-toAml connects-toMesothelioma connects-toHepatic Lobule connects-toPolycythemia Vera connects-toMyocardium connects-toOvarian Cancer connects-toMds connects-toColorectal Cancer connects-toMyc connects-toEzh2 connects-toTert connects-toCyclin D1 connects-toCdk4 6 connects-toHif 1Alpha connects-toCxcl12 connects-toTgf Beta connects-toNotch connects-toCaspase 3 connects-toCcl2 connects-toFgfr connects-toPik3Ca connects-toPdgf connects-toE2F1 connects-toErk1 2 connects-toPten connects-toCdh1 connects-toRb1 connects-toKras connects-toMdm2 connects-toCgas Sting connects-toStat1 connects-toGalectin 3 connects-toSmad4 connects-toFoxo connects-toPerforin connects-toGsk 3B connects-toS100A8 A9 connects-toSrc Kinase connects-toDnmt3A connects-toAutophagy connects-toArid1A connects-toAmpk connects-toCcr5 connects-toIl 6 connects-toIl 1B connects-toIl 33 connects-toIl 17A connects-toTestosterone connects-toMhc Class Ii connects-toGrowth Hormone connects-toIl 2 connects-toTroponin Complex connects-toHemoglobin connects-toAngiotensin Ii connects-toXanthine Oxidase connects-toIl 10 connects-toIl 4 connects-toIron connects-toProton connects-toIl 13 connects-toHeart connects-toT Cytotoxic Cell connects-toLeptin connects-toAdiponectin connects-toResistin connects-toType I Interferon connects-toIfn Gamma connects-toIl 12 connects-toIl 5 connects-toIl 23 connects-toIge connects-toMast Cell connects-toT Helper Cell connects-toB Cell connects-toComplement C3 connects-toC5Ar1 connects-toFactor H connects-toTslp connects-toBradykinin connects-toPeriostin connects-toC1 Esterase Inhibitor connects-toHistamine connects-toComplement C5 connects-toMelatonin connects-toSerotonin connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toCopper connects-toZinc connects-toPotassium connects-toCalcium connects-toCarbon connects-toChloride connects-toHydrogen connects-toNitrogen connects-toSulfur connects-toPhosphorus connects-toPd 1 connects-toGlp 1 connects-toRankl connects-toFibronectin connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toEpinephrine connects-toMyostatin connects-toAngiopoietin

Sources