Atlas One · Host Biology · Scale 03 — Molecular

DICER1

DICER1 is the dsRNA endonuclease that processes pre-miRNA to mature miRNA via RNase IIIa (3p) and RNase IIIb (5p) cleavage; somatic RNase IIIb hotspot mutations selectively impair 5p miRNA production; germline LOF + hotspot second hit = DICER1 syndrome tumors.

Also known as: DICER1, Dicer, DICER1 RNase III, DICER1 miRNA, DICER1 tumor, DICER1 hotspot, DICER1 PPB, DICER1 syndrome gene, RNase IIIb DICER1

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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dicer1

DICER1

DICER1 is the dsRNA endonuclease that processes pre-miRNA to mature miRNA via RNase IIIa (3p) and RNase IIIb (5p) cleavage; somatic RNase IIIb hotspot mutations selectively impair 5p miRNA production; germline LOF + hotspot second hit = DICER1 syndrome tumors.

Entry Metadata

FieldValue
IDdicer1
NameDICER1
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toDicer1 Syndrome connects-toMycn connects-toOvarian Cancer connects-toThyroid Cancer connects-toLung connects-toP53 connects-toWilms Tumor

Sources