Atlas One · Host Biology · Scale 03 — Molecular

PALB2

PALB2 bridges BRCA1 (coiled-coil N-terminus) to BRCA2 (WD40 C-terminus) at DSBs to enable RAD51-mediated homologous recombination; germline PALB2 = high-risk HBOC (~35-65% breast cancer); biallelic PALB2 = Fanconi anemia FA-N; HRD → PARP inhibitor sensitivity.

Also known as: PALB2, Partner and Localizer of BRCA2, FANCN, Fanconi PALB2, PALB2 BRCA1 BRCA2, PALB2 breast cancer, PALB2 WD40, PALB2 HR, PALB2 HBOC

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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palb2

PALB2

PALB2 bridges BRCA1 (coiled-coil N-terminus) to BRCA2 (WD40 C-terminus) at DSBs to enable RAD51-mediated homologous recombination; germline PALB2 = high-risk HBOC (~35-65% breast cancer); biallelic PALB2 = Fanconi anemia FA-N; HRD → PARP inhibitor sensitivity.

Entry Metadata

FieldValue
IDpalb2
NamePALB2
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toBrca1 connects-toBrca2 connects-toRad51 connects-toHereditary Breast Ovarian Cancer

Sources