Atlas One · Host Biology · Scale 03 — Molecular

CTNNA1

CTNNA1 (alpha-E-catenin) links E-cadherin–β-catenin to F-actin to maintain epithelial adhesion; LOF → loss of cadherin-cytoskeleton coupling → diffuse growth pattern; somatic CTNNA1 loss drives signet ring cell GC; germline CTNNA1 = HDGC in CDH1-negative families.

Also known as: CTNNA1, alpha-E-catenin, alpha-catenin, CTNNA1 HDGC, CTNNA1 gastric cancer, alpha-catenin E-cadherin, CTNNA1 tumor suppressor, alpha-catenin actin, cadherin-catenin complex

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
ctnna1

CTNNA1

CTNNA1 (alpha-E-catenin) links E-cadherin–β-catenin to F-actin to maintain epithelial adhesion; LOF → loss of cadherin-cytoskeleton coupling → diffuse growth pattern; somatic CTNNA1 loss drives signet ring cell GC; germline CTNNA1 = HDGC in CDH1-negative families.

Entry Metadata

FieldValue
IDctnna1
NameCTNNA1
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toCdh1 connects-toCtnnb1 connects-toGastric Cancer connects-toHereditary Diffuse Gastric Cancer connects-toBreast Cancer connects-toWnt Beta Catenin connects-toApc

Sources