Atlas One · Host Biology · Scale 07 — System

Marfan Syndrome

Marfan syndrome is caused by germline FBN1 mutations; aortic root dilation (risk of dissection), ectopia lentis, tall stature with long limbs and arachnodactyly; losartan and beta-blockers slow aortic growth; prophylactic aortic surgery when root diameter reaches 5.0 cm.

Also known as: Marfan syndrome, Marfan's syndrome, FBN1 syndrome, fibrillin-1 Marfan, Marfan aortic aneurysm, Marfan aortic dissection, Marfan ectopia lentis, Marfan connective tissue, MFS, Marfan cardiovascular

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
marfan-syndrome

Marfan Syndrome

Marfan syndrome is caused by germline FBN1 mutations; aortic root dilation (risk of dissection), ectopia lentis, tall stature with long limbs and arachnodactyly; losartan and beta-blockers slow aortic growth; prophylactic aortic surgery when root diameter reaches 5.0 cm.

Entry Metadata

FieldValue
IDmarfan-syndrome
NameMarfan Syndrome
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toFbn1 connects-toTgf Beta connects-toSmad4 connects-toCollagen connects-toAngiotensin Ii connects-toFibronectin connects-toHypertension connects-toHeart connects-toEye connects-toMusculoskeletal System connects-toCardiovascular System connects-toSmooth Muscle Cell connects-toLung connects-toFibroblast connects-toSkin connects-toStroke connects-toRespiratory System connects-toOsteoblast connects-toNervous System connects-toIntegumentary System connects-toReproductive System connects-toGrowth Hormone connects-toCardiomyocyte connects-toFibrosis connects-toEndothelial Cell connects-toOxygen connects-toMast Cell connects-toMtor connects-toBrain connects-toAkt connects-toNf Kb connects-toNitrogen connects-toAlveolus connects-toNeuron connects-toPhoton connects-toCalcium connects-toPdgf connects-toElectron connects-toLarge Intestine connects-toKidney connects-toOsteoclast connects-toPlacenta connects-toMagnesium connects-toOsteoporosis connects-toAdipocyte connects-toGeneralized Anxiety Disorder connects-toErk1 2 connects-toHeart Failure connects-toCopd connects-toNitric Oxide connects-toEndothelin 1 connects-toVenous Thromboembolism connects-toConnexin43 connects-toTroponin Complex connects-toMajor Depressive Disorder connects-toSepsis connects-toCkd connects-toPulmonary Arterial Hypertension connects-toWound Healing connects-toNeuropathic Pain connects-toInsomnia Disorder connects-toDigestive System connects-toRenal System connects-toEndocrine System connects-toImmune System connects-toStaphylococcus Aureus connects-toBeta Blockers connects-toArbs connects-toWarfarin connects-toAspirin connects-toArterial Wall connects-toCalcium Channel Blockers connects-toCortical Bone connects-toEndocardium connects-toCardiac Conduction System connects-toJuvenile Polyposis Syndrome connects-toMyocardium connects-toPeripheral Nerve connects-toSystemic Sclerosis connects-toAtherosclerosis connects-toBnp connects-toIgf 1 connects-toCaspase 3 connects-toT Cytotoxic Cell connects-toVegf connects-toCcl2 connects-toIl 6 connects-toTnf Alpha connects-toAldosterone connects-toRankl connects-toAdrenomedullin connects-toBeta1 Adrenergic Receptor connects-toEstrogen connects-toIl 1B connects-toPeriostin connects-toGalectin 3 connects-toRenin connects-toPik3Ca connects-toIl 17A connects-toComplement C3 connects-toKras connects-toNfe2L2 connects-toMyd88 connects-toJak1 2 connects-toStat3 connects-toPten connects-toCgas Sting connects-toStat1 connects-toFoxo connects-toGsk 3B connects-toHif 1Alpha connects-toS100A8 A9 connects-toAmpk connects-toAutophagy connects-toSrc Kinase connects-toCcr5 connects-toDnmt3A connects-toNotch connects-toCxcl12 connects-toArid1A connects-toIl 33 connects-toCalcineurin connects-toAdenosine connects-toOsteopontin connects-toXanthine Oxidase connects-toInsulin Receptor connects-toProgesterone connects-toVon Willebrand Factor connects-toProstaglandins connects-toIl 10 connects-toSerotonin connects-toIl 13 connects-toCopper connects-toZinc connects-toIl 4 connects-toHistamine connects-toZinc connects-toLeptin connects-toAdiponectin connects-toResistin connects-toMacrophage connects-toIfn Gamma connects-toIl 12 connects-toType I Interferon connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Helper Cell connects-toC5Ar1 connects-toComplement C5 connects-toNatural Killer Cell connects-toTslp connects-toBradykinin connects-toFactor H connects-toC1 Esterase Inhibitor connects-toErythropoietin connects-toMelatonin connects-toTestosterone connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toSelenium connects-toIodine connects-toSodium connects-toPotassium connects-toPhosphorus connects-toIron connects-toChloride connects-toSulfur connects-toCarbon connects-toHydrogen connects-toPd 1 connects-toGlp 1 connects-toWnt Beta Catenin connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toCgrp connects-toCalcitonin connects-toTgf Beta connects-toSubstance P connects-toInsulin Receptor connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toFgfr connects-toEpinephrine connects-toMyostatin connects-toAngiopoietin connects-toCortisol

Sources