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warfarin
Warfarin
Vitamin K antagonist anticoagulant; inhibits VKORC1 → depletes γ-carboxylated clotting factors II, VII, IX, X. Narrow therapeutic index (INR 2–3); major food/drug interactions via CYP2C9/VKORC1. Cornerstone of AF stroke prevention for 60+ years.
Entry Metadata
| Field | Value |
|---|---|
| ID | warfarin |
| Name | Warfarin |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Stream | 01-modern |
Cross-Atlas Connections
Sources
- Link KP. The discovery of dicumarol and its sequels. Circulation. 1959;19(1):97-107. · PubMed 13619027
- Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361(12):1139-51. · PubMed 19717844
- Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med. 2007;146(12):857-67. · PubMed 17577005
- Johnson JA, Gong L, Whirl-Carrillo M, et al. Clinical pharmacogenomics implementation consortium guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosing. Clin Pharmacol Ther. 2011;90(4):625-9. · PubMed 21900891