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cd30
CD30
CD30 (TNFRSF8) is a TNF receptor family member expressed on Reed-Sternberg cells (~100% cHL), ALCL (~100%), and activated lymphocytes; CD30L → TRAF2/5 → NF-κB; brentuximab vedotin (anti-CD30 ADC, MMAE) is the principal CD30-targeting therapy across cHL, ALCL, and CD30+ PTCL.
Entry Metadata
| Field | Value |
|---|---|
| ID | cd30 |
| Name | CD30 |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Connors JM, Jurczak W, Straus DJ, et al. Brentuximab vedotin with chemotherapy for stage III or IV Hodgkin's lymphoma. N Engl J Med. 2018;378(4):331-344. · PubMed 29360494
- Pro B, Advani R, Brice P, et al. Brentuximab vedotin (SGN-35) in patients with relapsed or refractory systemic anaplastic large-cell lymphoma: results of a phase II study. J Clin Oncol. 2012;30(18):2190-2196. · PubMed 22614995