Phospholamban

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phospholamban

Phospholamban (PLN, gene PLN) — 52-aa transmembrane micropeptide that tonically inhibits SERCA2a by reducing Ca²⁺ affinity (Km ~0.2→0.6 µM). PKA (Ser16) and CaMKII (Thr17) phosphorylation reverse inhibition, producing lusitropy and increased SR Ca²⁺ loading.

Entry Metadata

Field	Value
ID	phospholamban
Name	Phospholamban
Status	draft
Last reviewed	2026-06-03
Atlas	01-human
Scale	03-molecular
Uniprot	P26678
Gene Symbol	PLN
Chromosome	6q22.31

Cross-Atlas Connections

modulatesSerca2A modulated-byBeta1 Adrenergic Receptor connects-toHeart Failure connects-toCardiovascular System

Sources

MacLennan DH, Kranias EG. Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol. 2003;4(7):566-77. · PubMed 12838339
Kranias EG, Bers DM. Calcium and cardiomyopathies. Subcell Biochem. 2007;45:523-37. · PubMed 18193649
Simmerman HK, Jones LR. Phospholamban: protein structure, mechanism of action, and role in cardiac function. Physiol Rev. 1998;78(4):921-47. · PubMed 9790566
Schmitt JP, Kamisago M, Asahi M, et al. Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science. 2003;299(5611):1410-3. · PubMed 12610310