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flcn
FLCN
FLCN (folliculin) forms the FLCN-FNIP complex acting as a GAP for RagC/D GTPases on lysosomes to regulate mTORC1 amino acid sensing; LOF → mTOR dysregulation and mitochondrial biogenesis; germline FLCN = Birt-Hogg-Dubé syndrome; chromophobe and hybrid oncocytic RCC.
Entry Metadata
| Field | Value |
|---|---|
| ID | flcn |
| Name | FLCN |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Nickerson ML, Warren MB, Toro JR, et al. Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome. Cancer Cell. 2002;2(2):157-164. · PubMed 12204536
- Tsun ZY, Bar-Peled L, Chantranupong L, et al. The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol Cell. 2013;52(4):495-505. · PubMed 24095279