Atlas One · Host Biology · Scale 03 — Molecular

FH

FH (fumarate hydratase) catalyzes fumarate → malate in the TCA cycle; LOF → fumarate accumulation → HIF-1α activation + TET2/KDM inhibition → epigenetic reprogramming; germline FH = HLRCC; somatic FH = FH-deficient RCC; 2SC IHC is a diagnostic biomarker.

Also known as: FH, fumarate hydratase, FH mutation, FH HLRCC, FH-deficient RCC, fumarate hydratase LOF, FH cancer, FH TCA cycle, fumarate oncometabolite, FH IHC

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
fh

FH

FH (fumarate hydratase) catalyzes fumarate → malate in the TCA cycle; LOF → fumarate accumulation → HIF-1α activation + TET2/KDM inhibition → epigenetic reprogramming; germline FH = HLRCC; somatic FH = FH-deficient RCC; 2SC IHC is a diagnostic biomarker.

Entry Metadata

FieldValue
IDfh
NameFH
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toTet2 connects-toHif 1Alpha connects-toVhl connects-toRenal Cell Carcinoma connects-toEgln1 connects-toIdh1 connects-toP53

Sources