Atlas One · Host Biology · Scale 03 — Molecular

BLM

BLM is a RecQ helicase that dissolves double Holliday junctions via the BTR complex to suppress crossover during homologous recombination; biallelic BLM LOF → Bloom syndrome — elevated SCE (~10x), growth retardation, immunodeficiency, and pan-cancer predisposition.

Also known as: BLM, Bloom syndrome helicase, BLM helicase, RECQL3, BLM RecQ helicase, Bloom syndrome BLM, BLM DNA repair, BLM sister chromatid exchange, BTR complex BLM

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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blm

BLM

BLM is a RecQ helicase that dissolves double Holliday junctions via the BTR complex to suppress crossover during homologous recombination; biallelic BLM LOF → Bloom syndrome — elevated SCE (~10x), growth retardation, immunodeficiency, and pan-cancer predisposition.

Entry Metadata

FieldValue
IDblm
NameBLM
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toBloom Syndrome connects-toBrca1 connects-toWrn connects-toColorectal Cancer connects-toRad51 connects-toAtm connects-toMlh1

Sources