Atlas One · Host Biology · Scale 07 — System

Thrombotic Thrombocytopenic Purpura

TTP is a life-threatening TMA caused by ADAMTS13 deficiency (<10%); ULVWF-platelet microthrombi → MAHA + thrombocytopenia + end-organ ischemia. Caplacizumab (anti-VWF; FDA 2019) + plasma exchange + rituximab is current first-line; untreated mortality ~90%.

Also known as: TTP, thrombotic thrombocytopenic purpura, iTTP, immune TTP, Upshaw-Schulman syndrome, congenital TTP, hereditary TTP, thrombotic microangiopathy TTP, MAHA TTP

Scale 07 — SystemScale
draftStatus
2026-06-07Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
thrombotic-thrombocytopenic-purpura

Thrombotic Thrombocytopenic Purpura

TTP is a life-threatening TMA caused by ADAMTS13 deficiency (<10%); ULVWF-platelet microthrombi → MAHA + thrombocytopenia + end-organ ischemia. Caplacizumab (anti-VWF; FDA 2019) + plasma exchange + rituximab is current first-line; untreated mortality ~90%.

Entry Metadata

FieldValue
IDthrombotic-thrombocytopenic-purpura
NameThrombotic Thrombocytopenic Purpura
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale07-system

Cross-Atlas Connections

connects-toAdamts13 connects-toVon Willebrand Factor connects-toImmunoglobulin G connects-toAhus connects-toPlatelet connects-toComplement C3 connects-toEndothelial Cell connects-toKidney connects-toBrain connects-toErythrocyte connects-toImmune Thrombocytopenia connects-toDisseminated Intravascular Coagulation connects-toSystemic Lupus Erythematosus connects-toStroke connects-toAntiphospholipid Syndrome connects-toHiv Aids connects-toPlasma Cell connects-toHeart connects-toThrombin connects-toB Cell connects-toImmune System connects-toSpleen connects-toCd20 connects-toPlacenta connects-toT Helper Cell connects-toHemoglobin connects-toCalcium connects-toCortisol connects-toOxygen connects-toDendritic Cell connects-toLarge Intestine connects-toPotassium connects-toPancreas connects-toBone Marrow connects-toPhoton connects-toElectron connects-toLiver connects-toNeuron connects-toCardiomyocyte connects-toSkin connects-toAntibody connects-toReproductive System connects-toEye connects-toNeutrophil connects-toGvhd connects-toComplement C5 connects-toFcrn connects-toEscherichia Coli connects-toSepsis connects-toStat3 connects-toNf Kb connects-toIl 6 connects-toCkd connects-toHeart Failure connects-toMajor Depressive Disorder connects-toPtsd connects-toHepatitis B Virus connects-toPneumocystis Jirovecii connects-toVaricella Zoster Virus connects-toDigestive System connects-toGeneralized Anxiety Disorder connects-toNervous System connects-toIntegumentary System connects-toCardiovascular System connects-toRenal System connects-toRespiratory System connects-toEndocrine System connects-toCorticosteroids connects-toLymphatic System connects-toMusculoskeletal System connects-toTargeted Therapy connects-toCancer Chemotherapy connects-toHeparin Induced Thrombocytopenia connects-toGlomerulus connects-toMyocardium connects-toSystemic Sclerosis connects-toArterial Wall connects-toGastric Cancer connects-toMalaria connects-toCovid 19 Disease connects-toPancreatic Cancer connects-toCardiac Conduction System connects-toMacrophage connects-toNlrp3 Inflammasome connects-toIl 1B connects-toNitric Oxide connects-toEndothelin 1 connects-toFibrinogen connects-toPf4 connects-toBaff connects-toTlr4 connects-toMhc Class Ii connects-toBcl 2 connects-toS100A8 A9 connects-toHif 1Alpha connects-toVegf connects-toBtk connects-toCtla 4 connects-toThrombopoietin connects-toAngiopoietin connects-toMyd88 connects-toJak1 2 connects-toC5Ar1 connects-toAkt connects-toErk1 2 connects-toGalectin 3 connects-toCgas Sting connects-toStat1 connects-toPik3Ca connects-toFoxo connects-toGsk 3B connects-toPerforin connects-toSrc Kinase connects-toMtor connects-toAutophagy connects-toAmpk connects-toCcr5 connects-toDnmt3A connects-toCxcl12 connects-toIl 33 connects-toIl 17A connects-toTroponin Complex connects-toCollagen connects-toProstaglandins connects-toSerotonin connects-toEstrogen connects-toPd 1 connects-toIl 10 connects-toIl 4 connects-toXanthine Oxidase connects-toIron connects-toIl 13 connects-toHepcidin connects-toType I Interferon connects-toResistin connects-toMagnesium connects-toHeart connects-toLeptin connects-toAdiponectin connects-toIfn Gamma connects-toIl 12 connects-toNatural Killer Cell connects-toIl 5 connects-toIl 23 connects-toIge connects-toT Cytotoxic Cell connects-toSelenium connects-toVitamin D connects-toFactor H connects-toC1 Esterase Inhibitor connects-toTransferrin connects-toTslp connects-toBradykinin connects-toErythropoietin connects-toHistamine connects-toPeriostin connects-toMelatonin connects-toTestosterone connects-toProlactin connects-toOxytocin connects-toVasopressin connects-toIodine connects-toSodium connects-toCopper connects-toZinc connects-toPhosphorus connects-toChloride connects-toSulfur connects-toNitrogen connects-toCarbon connects-toHydrogen connects-toGlp 1 connects-toAngiotensin Ii connects-toWnt Beta Catenin connects-toRankl connects-toSmad4 connects-toIl 2 connects-toFibronectin connects-toNotch connects-toIgf 1 connects-toActivin A connects-toTgf Beta connects-toCgrp connects-toCalcitonin connects-toSubstance P connects-toInsulin Receptor connects-toAldosterone connects-toAndrogen Receptor connects-toNorepinephrine connects-toAdrenomedullin connects-toBdnf connects-toOsteopontin connects-toFgfr