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thrombotic-thrombocytopenic-purpura
Thrombotic Thrombocytopenic Purpura
TTP is a life-threatening TMA caused by ADAMTS13 deficiency (<10%); ULVWF-platelet microthrombi → MAHA + thrombocytopenia + end-organ ischemia. Caplacizumab (anti-VWF; FDA 2019) + plasma exchange + rituximab is current first-line; untreated mortality ~90%.
Entry Metadata
| Field | Value |
|---|---|
| ID | thrombotic-thrombocytopenic-purpura |
| Name | Thrombotic Thrombocytopenic Purpura |
| Status | draft |
| Last reviewed | 2026-06-07 |
| Atlas | 01-human |
| Scale | 07-system |
Cross-Atlas Connections
connects-toAdamts13
connects-toVon Willebrand Factor
connects-toImmunoglobulin G
connects-toAhus
connects-toPlatelet
connects-toComplement C3
connects-toEndothelial Cell
connects-toKidney
connects-toBrain
connects-toErythrocyte
connects-toImmune Thrombocytopenia
connects-toDisseminated Intravascular Coagulation
connects-toSystemic Lupus Erythematosus
connects-toStroke
connects-toAntiphospholipid Syndrome
connects-toHiv Aids
connects-toPlasma Cell
connects-toHeart
connects-toThrombin
connects-toB Cell
connects-toImmune System
connects-toSpleen
connects-toCd20
connects-toPlacenta
connects-toT Helper Cell
connects-toHemoglobin
connects-toCalcium
connects-toCortisol
connects-toOxygen
connects-toDendritic Cell
connects-toLarge Intestine
connects-toPotassium
connects-toPancreas
connects-toBone Marrow
connects-toPhoton
connects-toElectron
connects-toLiver
connects-toNeuron
connects-toCardiomyocyte
connects-toSkin
connects-toAntibody
connects-toReproductive System
connects-toEye
connects-toNeutrophil
connects-toGvhd
connects-toComplement C5
connects-toFcrn
connects-toEscherichia Coli
connects-toSepsis
connects-toStat3
connects-toNf Kb
connects-toIl 6
connects-toCkd
connects-toHeart Failure
connects-toMajor Depressive Disorder
connects-toPtsd
connects-toHepatitis B Virus
connects-toPneumocystis Jirovecii
connects-toVaricella Zoster Virus
connects-toDigestive System
connects-toGeneralized Anxiety Disorder
connects-toNervous System
connects-toIntegumentary System
connects-toCardiovascular System
connects-toRenal System
connects-toRespiratory System
connects-toEndocrine System
connects-toCorticosteroids
connects-toLymphatic System
connects-toMusculoskeletal System
connects-toTargeted Therapy
connects-toCancer Chemotherapy
connects-toHeparin Induced Thrombocytopenia
connects-toGlomerulus
connects-toMyocardium
connects-toSystemic Sclerosis
connects-toArterial Wall
connects-toGastric Cancer
connects-toMalaria
connects-toCovid 19 Disease
connects-toPancreatic Cancer
connects-toCardiac Conduction System
connects-toMacrophage
connects-toNlrp3 Inflammasome
connects-toIl 1B
connects-toNitric Oxide
connects-toEndothelin 1
connects-toFibrinogen
connects-toPf4
connects-toBaff
connects-toTlr4
connects-toMhc Class Ii
connects-toBcl 2
connects-toS100A8 A9
connects-toHif 1Alpha
connects-toVegf
connects-toBtk
connects-toCtla 4
connects-toThrombopoietin
connects-toAngiopoietin
connects-toMyd88
connects-toJak1 2
connects-toC5Ar1
connects-toAkt
connects-toErk1 2
connects-toGalectin 3
connects-toCgas Sting
connects-toStat1
connects-toPik3Ca
connects-toFoxo
connects-toGsk 3B
connects-toPerforin
connects-toSrc Kinase
connects-toMtor
connects-toAutophagy
connects-toAmpk
connects-toCcr5
connects-toDnmt3A
connects-toCxcl12
connects-toIl 33
connects-toIl 17A
connects-toTroponin Complex
connects-toCollagen
connects-toProstaglandins
connects-toSerotonin
connects-toEstrogen
connects-toPd 1
connects-toIl 10
connects-toIl 4
connects-toXanthine Oxidase
connects-toIron
connects-toIl 13
connects-toHepcidin
connects-toType I Interferon
connects-toResistin
connects-toMagnesium
connects-toHeart
connects-toLeptin
connects-toAdiponectin
connects-toIfn Gamma
connects-toIl 12
connects-toNatural Killer Cell
connects-toIl 5
connects-toIl 23
connects-toIge
connects-toT Cytotoxic Cell
connects-toSelenium
connects-toVitamin D
connects-toFactor H
connects-toC1 Esterase Inhibitor
connects-toTransferrin
connects-toTslp
connects-toBradykinin
connects-toErythropoietin
connects-toHistamine
connects-toPeriostin
connects-toMelatonin
connects-toTestosterone
connects-toProlactin
connects-toOxytocin
connects-toVasopressin
connects-toIodine
connects-toSodium
connects-toCopper
connects-toZinc
connects-toPhosphorus
connects-toChloride
connects-toSulfur
connects-toNitrogen
connects-toCarbon
connects-toHydrogen
connects-toGlp 1
connects-toAngiotensin Ii
connects-toWnt Beta Catenin
connects-toRankl
connects-toSmad4
connects-toIl 2
connects-toFibronectin
connects-toNotch
connects-toIgf 1
connects-toActivin A
connects-toTgf Beta
connects-toCgrp
connects-toCalcitonin
connects-toSubstance P
connects-toInsulin Receptor
connects-toAldosterone
connects-toAndrogen Receptor
connects-toNorepinephrine
connects-toAdrenomedullin
connects-toBdnf
connects-toOsteopontin
connects-toFgfr
Sources
- Scully M, Cataland SR, Peyvandi F, et al. Caplacizumab treatment for acquired thrombotic thrombocytopenic purpura. N Engl J Med. 2019;380(4):335-346. · PubMed 30625070
- George JN. Clinical practice. Thrombotic thrombocytopenic purpura. N Engl J Med. 2006;354(18):1927-1935. · PubMed 16672704
- Coppo P, Busson M, Veyradier A, et al. HLA-DRB1*11: a strong risk factor for acquired severe ADAMTS13 deficiency-related thrombotic thrombocytopenic purpura in Caucasians. J Thromb Haemost. 2010;8(11):2466-2469. · PubMed 20735727