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sars-cov-2-spike
SARS-CoV-2 Spike
SARS-CoV-2 Spike (class I fusogen; 1273 aa; homotrimer; furin site PRRAR absent in SARS-CoV-1) binds ACE2 (Kd ~15 nM) via RBD; 2P (K986P/V987P) proline stabilization locks prefusion conformation for mRNA vaccines; Omicron BA.1 carries 37 Spike mutations driving antibody escape.
Entry Metadata
| Field | Value |
|---|---|
| ID | sars-cov-2-spike |
| Name | SARS-CoV-2 Spike |
| Status | draft |
| Last reviewed | 2026-06-08 |
| Atlas | 01-human |
| Scale | 03-molecular |
Cross-Atlas Connections
Sources
- Wrapp D, Wang N, Corbett KS, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020;367(6483):1260-1263. · PubMed 32075877
- Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181(2):271-280. · PubMed 32142651
- Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein. Cell. 2020;181(2):281-292. · PubMed 32155444
- Hsieh CL, Goldsmith JA, Schaub JM, et al. Structure-based design of prefusion-stabilized SARS-CoV-2 spikes. Science. 2020;369(6510):1501-1505. · PubMed 32703906