Atlas One · Host Biology · Scale 03 — Molecular

HIV gp120

HIV gp120 (surface subunit of Env; ~120 kDa; 27 N-linked glycans) binds CD4 (Phe43 cavity) then CCR5/CXCR4 to trigger gp41 fusion; glycan shield conceals bNAb epitopes; CD4-binding site, V1V2 apex, and MPER are targets of VRC01, PG9, and SOSIP vaccine immunogens.

Also known as: HIV gp120, HIV envelope glycoprotein, HIV Env, gp120, gp160, HIV gp41, broadly neutralizing antibody HIV, bNAb, SOSIP, VRC01, CD4-binding site antibody, HIV vaccine gp120

Scale 03 — MolecularScale
draftStatus
2026-06-08Last Reviewed
This is an auto-generated stub page built from atlas entry frontmatter. A richer hand-crafted page is planned. See the atlas source for the full entry including detailed body sections.
hiv-gp120

HIV gp120

HIV gp120 (surface subunit of Env; ~120 kDa; 27 N-linked glycans) binds CD4 (Phe43 cavity) then CCR5/CXCR4 to trigger gp41 fusion; glycan shield conceals bNAb epitopes; CD4-binding site, V1V2 apex, and MPER are targets of VRC01, PG9, and SOSIP vaccine immunogens.

Entry Metadata

FieldValue
IDhiv-gp120
NameHIV gp120
Statusdraft
Last reviewed2026-06-08
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toHiv connects-toMavs connects-toCgas Sting connects-toType I Interferon connects-toNf Kb connects-toRsv F Protein

Sources