Atlas One · Host Biology · Scale 03 — Molecular

LRRK2

LRRK2 encodes a dual GTPase-kinase; G2019S (most common pathogenic variant) hyperactivates LRRK2 kinase → Rab GTPase hyperphosphorylation → autophagy and vesicle trafficking dysfunction → α-synuclein accumulation; LRRK2 inhibitors are in Phase 2 trials for Parkinson disease.

Also known as: LRRK2, leucine-rich repeat kinase 2, PARK8, dardarin, LRRK2 G2019S, LRRK2 kinase, LRRK2 Parkinson, LRRK2 inhibitor, ROCO protein, LRRK2 GTPase

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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lrrk2

LRRK2

LRRK2 encodes a dual GTPase-kinase; G2019S (most common pathogenic variant) hyperactivates LRRK2 kinase → Rab GTPase hyperphosphorylation → autophagy and vesicle trafficking dysfunction → α-synuclein accumulation; LRRK2 inhibitors are in Phase 2 trials for Parkinson disease.

Entry Metadata

FieldValue
IDlrrk2
NameLRRK2
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toParkinsons Disease connects-toAutophagy connects-toSnca connects-toMtor

Sources