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akkermansia-muciniphila
Akkermansia muciniphila
Gram-negative anaerobe (Verrucomicrobia); mucin-degrading specialist in the inner mucus layer. Amuc_1100 outer membrane protein signals TLR2 → tight junctions + IL-10. Produces propionate/acetate; inversely correlated with obesity, T2DM, and IBD.
Entry Metadata
| Field | Value |
|---|---|
| ID | akkermansia-muciniphila |
| Name | Akkermansia muciniphila |
| Status | draft |
| Last reviewed | 2026-06-05 |
| Class | 06-microbiome |
Cross-Atlas Connections
Sources
- Plovier H, Everard A, Druart C, et al. A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium improves metabolism in obese and diabetic mice. Nat Med. 2017;23(1):107-13. · PubMed 27892954
- Depommier C, Everard A, Druart C, et al. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nat Med. 2019;25(7):1096-103. · PubMed 31263284
- Hall JE, Hall ME. Guyton and Hall Textbook of Medical Physiology. 14th ed. Elsevier; 2021.
- Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 7th ed. W.W. Norton; 2022.