HCN4

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hcn4

HCN4 (Hyperpolarization-activated Cyclic Nucleotide-gated channel 4, gene HCN4) — cardiac funny current (I_f). Activated by hyperpolarisation at ~−60 mV; carries mixed Na⁺/K⁺ inward current; directly gated by cAMP. Dominant pacemaker channel of the SA node; ivabradine target.

Entry Metadata

Field	Value
ID	hcn4
Name	HCN4
Status	draft
Last reviewed	2026-06-03
Atlas	01-human
Scale	03-molecular
Uniprot	Q9Y3Q4
Gene Symbol	HCN4
Chromosome	15q24.1

Cross-Atlas Connections

expressed-bySa Node Cell modulated-byBeta1 Adrenergic Receptor connects-toHeart Failure connects-toCardiovascular System

Sources

DiFrancesco D. The role of the funny current in pacemaker activity. Circ Res. 2010;106(3):434-46. · PubMed 20167941
Baruscotti M, Bucchi A, Viscomi C, et al. Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4. Proc Natl Acad Sci USA. 2011;108(4):1705-10. · PubMed 21205885
Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M. A family of hyperpolarization-activated mammalian cation channels. Nature. 1998;393(6685):587-91. · PubMed 9634236
Stieber J, Herrmann S, Feil S, et al. The hyperpolarization-activated channel HCN4 underlies the If current in sinoatrial node myocytes. J Biol Chem. 2003;278(36):33672-80. · PubMed 12826672