Atlas One · Host Biology · Scale 03 — Molecular

Desmoglein-3

Desmoglein-3 (DSG3; chr18q12.1) is a desmosomal cadherin in stratified epithelia; anti-Dsg3 IgG4 causes pemphigus vulgaris (mucosal) and anti-Dsg1 IgG4 causes pemphigus foliaceus (superficial). Rituximab (FDA 2018) and efgartigimod (FDA 2023) are approved treatments.

Also known as: DSG3, desmoglein-3, desmoglein 3, Dsg3, anti-Dsg3, pemphigus antigen

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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desmoglein-3

Desmoglein-3

Desmoglein-3 (DSG3; chr18q12.1) is a desmosomal cadherin in stratified epithelia; anti-Dsg3 IgG4 causes pemphigus vulgaris (mucosal) and anti-Dsg1 IgG4 causes pemphigus foliaceus (superficial). Rituximab (FDA 2018) and efgartigimod (FDA 2023) are approved treatments.

Entry Metadata

FieldValue
IDdesmoglein-3
NameDesmoglein-3
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toPemphigus Vulgaris connects-toImmunoglobulin G connects-toCd20 connects-toFcrn part-ofSkin

Sources