Atlas One · Host Biology · Scale 03 — Molecular

KLLN

KLLN (KILLIN) is a p53 transcriptional target that binds PCNA to stall DNA replication forks during S-phase; germline KLLN promoter hypermethylation silences KLLN in PTEN-mutation-negative Cowden syndrome; LOF → unconstrained replication → genomic instability → tumorigenesis.

Also known as: KLLN, KILLIN, KLLN tumor suppressor, KLLN PCNA, KLLN p53 target, KLLN Cowden syndrome, KLLN epigenetic silencing, KILLIN DNA replication, KLLN 10q23

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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klln

KLLN

KLLN (KILLIN) is a p53 transcriptional target that binds PCNA to stall DNA replication forks during S-phase; germline KLLN promoter hypermethylation silences KLLN in PTEN-mutation-negative Cowden syndrome; LOF → unconstrained replication → genomic instability → tumorigenesis.

Entry Metadata

FieldValue
IDklln
NameKLLN
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toCowden Syndrome connects-toPten connects-toP53 connects-toMtor

Sources