Atlas Four · Vaccine Atlas · Platform 05 — Live-Attenuated

OPV (Oral Polio Vaccine / Sabin trivalent)

Trivalent live-attenuated oral poliovirus vaccine (Sabin strains). Gut replication induces mucosal sIgA + systemic IgG. WHO Polio Eradication cornerstone; eliminated WPV2 (2015) and WPV3 (2019). Risks: VAPP (~1:750,000 first doses) and vaccine-derived poliovirus (cVDPV).

05 — Live-AttenuatedPlatform
oralRoute
2–8°C; heat-sensitive; VVM (vaccine vial monitor) mandatoryCold Chain
activeStatus
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oral-polio-vaccine

OPV (Oral Polio Vaccine / Sabin trivalent)

Trivalent live-attenuated oral poliovirus vaccine (Sabin strains). Gut replication induces mucosal sIgA + systemic IgG. WHO Polio Eradication cornerstone; eliminated WPV2 (2015) and WPV3 (2019). Risks: VAPP (~1:750,000 first doses) and vaccine-derived poliovirus (cVDPV).

Entry Metadata

FieldValue
IDoral-polio-vaccine
NameOPV (Oral Polio Vaccine / Sabin trivalent)
Statusactive
Last reviewed2026-06-06
Platform05 — Live-Attenuated
Delivery systemlive attenuated virus, oral solution
AdjuvantsNone
Routeoral
Dose schedule3 doses at 6, 10, 14 weeks (EPI schedule); can be given at birth as a 0-dose; booster at 18 months
Manufacturermultiple (Bio Farma, Serum Institute of India, Panacea Biotec, BCHT, Sanofi)
Cold chain2–8°C; heat-sensitive; VVM (vaccine vial monitor) mandatory

Cross-Atlas Connections

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Sources