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varivax
Varivax
Live-attenuated VZV Oka strain varicella vaccine. Two-dose schedule (12-15 months + 4-6 years) achieves >95% seroconversion; 97-100% protection against severe varicella. Contraindicated in immunocompromised patients and pregnancy.
Entry Metadata
| Field | Value |
|---|---|
| ID | varivax |
| Name | Varivax |
| Status | active |
| Last reviewed | 2026-06-06 |
| Platform | 05 — Live-Attenuated |
| Delivery system | lyophilized live attenuated virus; reconstituted with sterile water |
| Adjuvants | None |
| Route | subcutaneous |
| Dose schedule | 2-dose series: dose 1 at 12-15 months; dose 2 at 4-6 years (minimum interval 3 months). Previously 1-dose schedule 1995-2006. |
| Manufacturer | Merck Sharp & Dohme (Merck) |
| Cold chain | Frozen storage at -15°C or colder during shipping; 2–8°C for up to 72 hours post-thaw; use immediately once reconstituted; discard if not used within 30 minutes |
Cross-Atlas Connections
Sources
- Weibel RE, Neff BJ, Kuter BJ, et al. Live attenuated varicella virus vaccine: efficacy trial in healthy children. N Engl J Med. 1984;310(22):1409-1415. · PubMed 6325883
- Vazquez M, LaRussa PS, Gershon AA, Steinberg SP, Freudigman K, Shapiro ED. The effectiveness of the varicella vaccine in clinical practice. N Engl J Med. 2001;344(13):955-960. · PubMed 11274621
- Marin M, Güris D, Chaves SS, Schmid S, Seward JF. Prevention of varicella: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2007;56(RR-4):1-40. · PubMed 17585291