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acyclovir
Acyclovir
Nucleoside analogue prodrug selectively activated by viral thymidine kinase to acyclovir triphosphate, which chain-terminates HSV/VZV DNA polymerase. First-line for HSV-1, HSV-2, VZV infections. Elion 1988 Nobel Prize in Physiology or Medicine.
Entry Metadata
| Field | Value |
|---|---|
| ID | acyclovir |
| Name | Acyclovir |
| Status | draft |
| Last reviewed | 2026-06-06 |
| Stream | 01-modern |
| Drug class | nucleoside analogue antiviral |
Cross-Atlas Connections
Sources
- Elion GB, Furman PA, Fyfe JA, et al. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine. Proc Natl Acad Sci USA. 1977;74(12):5716-20. · PubMed 202961
- Whitley RJ, Gnann JW Jr. Acyclovir: a decade later. N Engl J Med. 1992;327(11):782-9. · PubMed 1501651
- Skoldenberg B, Forsgren M, Alestig K, et al. Acyclovir versus vidarabine in herpes simplex encephalitis. Randomised multicentre study in consecutive Swedish patients. Lancet. 1984;2(8405):707-11. · PubMed 6148571