Atlas One · Host Biology · Scale 03 — Molecular

PRKAR1A

PRKAR1A (R1α) is the regulatory subunit 1α of cAMP-dependent PKA that sequesters the catalytic subunit; cAMP → R1α dissociation → PKA active → CREB/StAR/steroidogenesis; germline PRKAR1A LOF → constitutive PKA → PPNAD/Cushing; somatic loss in adrenocortical tumors.

Also known as: PRKAR1A, R1alpha, PKA regulatory subunit, PRKAR1A Carney complex, protein kinase A regulatory, PRKAR1A PPNAD, PRKAR1A tumor suppressor, cAMP PKA PRKAR1A, R1alpha PKA

Scale 03 — MolecularScale
draftStatus
2026-06-07Last Reviewed
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prkar1a

PRKAR1A

PRKAR1A (R1α) is the regulatory subunit 1α of cAMP-dependent PKA that sequesters the catalytic subunit; cAMP → R1α dissociation → PKA active → CREB/StAR/steroidogenesis; germline PRKAR1A LOF → constitutive PKA → PPNAD/Cushing; somatic loss in adrenocortical tumors.

Entry Metadata

FieldValue
IDprkar1a
NamePRKAR1A
Statusdraft
Last reviewed2026-06-07
Atlas01-human
Scale03-molecular

Cross-Atlas Connections

connects-toCarney Complex connects-toCortisol connects-toGlucocorticoid Receptor connects-toPheochromocytoma Paraganglioma connects-toEpinephrine connects-toMtor connects-toErk1 2

Sources