Atlas One · Human · Level 04

Cellular

The smallest unit that is unambiguously alive. 37.2 trillion cells, 200+ distinct types.

Each cell type integrates signals from the molecular layer below and contributes function to the tissue layer above. From the immune synapse to the cardiac action potential, from liver metabolism to bone remodeling — every physiological process is ultimately a cell behavior.

28Entries
37.2TTotal cells
200+Distinct cell types
~1MCells replaced per second

The cell is the fundamental unit of biology — the smallest structure that grows, replicates, responds to environment, and dies by program or accident. The human body maintains 37.2 trillion of them simultaneously: immune cells patrolling for pathogens and tumors, cardiomyocytes firing 100,000 times a day for a lifetime, neurons holding synaptic weights that encode memory, hepatocytes performing thousands of metabolic reactions per second. Each cell type in the atlas is modeled with its origin, defining proteins, signaling state, functional role, failure modes, and connections to the molecules below and the tissues above it.

Level 04 — Cellular

Immune, Cardiovascular, Neural, and Metabolic Cells

28 entries organized by functional class. Each entry links structure, signaling, tissue context, and disease relevance.

Immune Cells

Phagocytosis; antigen presentation; cytokine release; foam cell in atherosclerosis; M2 in fibrosis MHC-I missing self surveillance; perforin/granzyme cytotoxicity; ADCC; NK cell deficiency; NK cell therapy Antibody production; antigen presentation to Tfh; class switching (IgM→IgG/A/E); CLL; rituximab (anti-CD20) B-cell help; macrophage activation; IFN-γ/IL-4/IL-17 cytokine programs; HIV CD4 depletion; checkpoint therapy Perforin/granzyme killing; Fas-FasL apoptosis; viral clearance; tumor immunosurveillance; CAR-T engineering IL-10/TGF-β immunosuppression; CTLA-4 constitutive expression; IPEX (FOXP3 mutation); Treg depletion in cancer therapy T-cell priming; CCR7 lymph node homing; type I IFN (pDC); vaccine adjuvant target; tolerogenic DC in autoimmunity 1000–10,000 Ab/sec; long-lived bone marrow niche; multiple myeloma; BCMA-targeted therapy; UPR dependence Histamine/tryptase/heparin granules; IgE crosslinking → anaphylaxis; anti-parasite defense; urticaria; omalizumab Phagocytosis; ROS burst; NET formation; first responder to infection; neutropenia risk; G-CSF mobilisation Primary hemostasis; TXA2/ADP amplification; GPIIb-IIIa fibrinogen bridge; antiplatelet drugs (aspirin/clopidogrel); ITP

Cardiovascular Cells

Hemoglobin O&sub2; transport; CO&sub2; as bicarbonate; Band 3 / spectrin cytoskeleton; sickle cell; thalassaemia; G6PD deficiency ~100,000 contractions/day; sarcomere Ca²&sup+;-troponin; ETC dependence; myocarditis; HCM/DCM mutations; limited regeneration I&sub⊂ (HCN4) spontaneous depolarization; sympathetic/vagal autonomic modulation; sick sinus; ivabradine; pacemaker therapy Barrier function; eNOS NO; coagulation balance; leukocyte transmigration (ICAM-1/VCAM-1); endotheliopathy; atherosclerosis Vascular tone (Ca²&sup+;/IP&sub3;); phenotypic switching in atherosclerosis; vascular fibrosis; PDGF proliferation; calcium-channel blockers

Neural Cells

Action potential; synaptic transmission; LTP/LTD; neurodegenerative vulnerability; Nav1.x/Kv/Ca&sub²&sup+; channel pharmacology Glutamate reuptake (GLT-1/GLAST); K&sup+; spatial buffering; BBB astrocyte end-feet; reactive astrogliosis; glymphatic clearance Synaptic pruning; neuroinflammation (M1/M2-like); TREM2 Alzheimer risk; CSF1R inhibitors; homeostatic vs. disease-associated Saltatory conduction (nodes of Ranvier); multiple sclerosis (demyelination); oligodendrocyte precursor (OPC) remyelination

Metabolic & Structural Cells

Albumin/coagulation factor synthesis; gluconeogenesis; cytochrome P450 drug metabolism; bile acid conjugation; NAFLD→NASH Triglyceride storage/lipolysis; leptin/adiponectin endocrine; BAT thermogenesis (UCP1); visceral adiposity risk; GLP-1 targets Collagen/ECM synthesis; myofibroblast differentiation in fibrosis; TGF-β signaling; wound healing; cardiac fibrosis Filtration barrier (slit diaphragm); podocyte injury → nephrotic syndrome; FSGS; minimal change disease; limited regeneration Hydroxyapatite mineralization; Wnt/BMP signaling; PTH anabolic vs. catabolic; osteoporosis; teriparatide mechanism Bone resorption via HCl + protease; RANKL inhibition (denosumab); bisphosphonate mechanism; Paget disease; metastatic bone disease Surfactant (DPPC/SP-A/B/C/D); alveolar surface tension; ARDS; neonatal RDS; SARS-CoV-2 ACE2 entry; ILD fibrosis progression

Help expand the Cellular Atlas

Many cell types remain to be filled: eosinophils, basophils, goblet cells, enterocytes, parietal cells, chief cells, Sertoli cells, granulosa cells, melanocytes, keratinocytes, and many more. Each entry follows the same open schema with peer-reviewed citations.